Motor neurone disease (MND) has long been regarded as one of the most heartbreaking diagnoses in modern medicine, gradually robbing individuals of their physical independence while leaving memory and cognition untouched. However, international research is entering a revolutionary new era. From groundbreaking gene-silencing therapies and AI-assisted drug discovery to early-detection blood tests and stem cell studies, scientists are shifting their focus from merely managing symptoms to targeting the root causes of the disease. These clinical advances provide genuine, evidence-based optimism for patients and families worldwide.

For many years, motor neurone disease (MND) has been regarded as one of the most heart-breaking illnesses in medicine. It gradually robs people of their ability to walk, use their hands, speak, swallow and eventually breathe, while often leaving their thinking and memory untouched. It is a cruel diagnosis, not only for those living with the disease but also for their families and loved ones.

Shortly after I graduated in the late eighties, I had to watch my grandfather die from motor neurone disease. At the time it wasn’t making headlines, and to be honest not many people had even heard of it. I had to pull some textbooks to try and understand the pathology, but even then, I was left much in the dark. I can remember thinking how little we really understood many conditions that affected us, and no amount of training can prepare you to witness something so horrid.

Since that time, we have learned a lot.

Researchers around the world are making faster progress than ever before. New discoveries about what causes MND are leading to treatments that target the disease itself rather than simply helping to manage its symptoms. There is still no cure, but many experts believe we are entering a new era in MND research.

What Is Motor Neurone Disease and How Does It Progress?

Motor neurones are the nerve cells that carry messages from the brain to the muscles. Every time you smile, lift a cup of coffee or take a step, these nerves are doing their job.

In people with MND, these nerve cells gradually stop working and die. As fewer signals reach the muscles, they become weaker and waste away. Everyday tasks become increasingly difficult, and as the disease progresses, patients often need more help with even the simplest activities.

Most people who develop MND have no family history of the condition. However, around one in ten cases are inherited, and understanding these inherited forms has opened exciting new avenues for research.

Targeted Gene Therapy: Stopping MND at Its Genetic Source

Perhaps the biggest breakthrough has been the development of treatments that target faulty genes.

Scientists have identified several genes that can cause inherited forms of MND. Instead of treating the symptoms, researchers have developed medicines that switch off these faulty genes before they can produce harmful proteins that damage nerve cells.

I know this all sounds a bit science fiction, and these treatments are only suitable for a small number of patients at present, but they prove that it is possible to slow the disease by tackling its underlying cause. That is a huge step forward and offers hope that similar treatments could eventually be developed for many more people.

How Artificial Intelligence Is Accelerating Medical Drug Discovery

Artificial intelligence, apparently it could put an end to all of us in the next ten years if you believe that, but the truth is that it is helping researchers make discoveries at an astonishing speed.

By analysing enormous amounts of medical information, AI can spot patterns that would take humans years to identify. It is helping scientists discover new drug targets, identify existing medicines that might be useful for MND, and even match suitable patients to clinical trials more quickly.

Of course AI doesn’t replace medical researchers—it simply gives them a remarkably powerful new tool.

Stem Cell Research: Protecting Healthy Nerve Cells

Stem cell research has attracted headlines for years, although the reality has often been less dramatic than the publicity suggested.

Today’s research is much more realistic. Scientists are no longer expecting stem cells to magically replace damaged nerves. Instead, they hope stem cells can protect the healthy nerve cells that remain by releasing substances that reduce inflammation and support nerve survival.

Early studies are encouraging, but much more research is needed before stem cell treatments become widely available. Unfortunately, political decisions still block this type of research in some regions.

Controlling Inflammation: Protecting the Nervous System

One of the biggest discoveries in recent years is that MND is not just a disease of nerve cells.

The body’s own support cells, which normally protect the nervous system, can become overactive and accidentally contribute to further damage by producing harmful inflammation.

This has led researchers to investigate medicines that calm this inflammation, potentially slowing the disease while leaving the immune system able to fight infections normally.

Earlier Diagnosis: The Role of Biomarkers and Blood Tests

Doctors are also getting better at diagnosing MND earlier.

Researchers have identified substances in the blood that can act as warning signs of nerve damage. One of the most promising is a protein called neurofilament light chain, which is released when nerve cells are injured.

A simple blood test may help doctors confirm the diagnosis sooner and monitor how quickly the disease is progressing.

This is important because many of the new treatments are likely to work best before too many nerve cells have been lost.

Multidisciplinary Care and Assisted Technology

While everyone hopes for a cure, improvements in everyday care have already made a real difference.

Patients today often benefit from specialist clinics where neurologists, physiotherapists, speech therapists, dietitians, respiratory specialists and nurses all work together. This team approach has been shown to improve both quality of life and survival.

Modern breathing support, nutritional advice and communication technology are also helping people remain independent for longer.

Eye-controlled computers, for example, allow many people who have lost their speech to continue communicating with family and friends using only their eye movements.

International Collaboration and Global Clinical Trials

One reason progress has accelerated is that researchers are no longer working in isolation.

MND is a relatively uncommon disease, so international collaboration has become essential. Scientists across Europe, North America, Australia and Asia are now sharing information and working together on large clinical trials, despite political interference.

Patient organisations have also played a vital role by funding research, raising awareness and encouraging people to take part in studies.

The Future of MND Care: Personalised Therapies and Hope

No one is pretending that MND has been solved. It remains one of the most complex neurological diseases doctors face, and much work still lies ahead.

However, the picture today is far brighter than it was even ten years ago. Scientists understand far more about why the disease develops, they have identified promising new treatment targets, and dozens of new therapies are being tested around the world.

Many experts now believe that the future will involve diagnosing MND much earlier and treating it with a combination of therapies tailored to each individual—rather like the way cancers and HIV are treated today.

For people living with motor neurone disease and those who love them, that offers something which, until recently, was in short supply: genuine reason for optimism.

Every new discovery brings us a little closer to the day when MND can be slowed significantly, controlled—or perhaps one day even prevented altogether.

While that day has not yet arrived, it no longer feels like an impossible dream.

If you, or a loved one, are affected by MND you can contact the Spanish MND association on Telephone 91 311 3530 or by email at adela@adelaweb.org.

The information provided in this column is for educational and informational purposes only, and does not constitute medical advice. It is not a substitute for a professional medical consultation, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health provider with any questions you may have regarding a medical condition.

Dr Marcus Stephan 

For more expert health advice, medical research updates and wellbeing stories, visit Euro Weekly News’ Health & Beauty section.

If you’ve ever stood in front of a shelf full of anti-wrinkle creams wondering whether the €5 one could possibly do the same job as the €50 one, you might want to hold onto your money. A new test by Spain’s consumer watchdog OCU found that most of the 13 creams it examined reduced wrinkle depth by just 10 to 20 per cent, while the price difference between some products was enormous. 

That doesn’t mean the creams did nothing, the results were much better when it came to hydration, with the products generally leaving skin feeling softer, more elastic and moisturised. But when it came to actually reducing wrinkles, the results were far less impressive. 

OCU puts 13 anti-wrinkle creams to the test

OCU tested 13 anti-wrinkle creams available in supermarkets, pharmacies and perfumeries in Spain, with prices of up to €60 per container. The products were put through laboratory testing alongside a month-long user trial.  Thirty women aged between 40 and 65 took part. All had mild or moderate crow’s feet, and the creams were used for 28 days under the supervision of a dermatologist.

Each participant applied the cream being tested to one half of her face and a placebo cream to the other. Researchers then measured changes in the depth of the wrinkles using specialist equipment designed to create three-dimensional images of the skin’s surface.  The results were fairly modest. Most of the creams reduced wrinkle depth by between 10 and 20 per cent (not much at all)! Only two products went beyond the 20 per cent mark.

The €51 cream versus the €3.99 cream

One of those two was Filorga Creme Time Filler, which reduced wrinkle depth by 20.5 per cent. It was also the most expensive cream in the test, costing an average of €51 for 50ml. The other was Cien Q10 Intense FPS 15, sold by Lidl, which reduced wrinkle depth by 20.3 per cent.

Its price? Just €3.99 for 50ml.  That means the Filorga cream cost around 13 times as much as the Cien product, despite the two achieving almost identical results in OCU’s wrinkle test. Neither was considered “very good” for reducing wrinkles, with OCU describing the anti-wrinkle effectiveness of the two as good. 

The creams were better at hydration

The more positive results came when OCU looked at hydration. The women taking part in the test generally reported that the creams felt pleasant to use, absorbed well and left their skin feeling softer, more elastic and hydrated. Laboratory measurements also confirmed good hydration results, although there were differences between the products. 

OCU’s overall conclusion was that these creams hydrate more than they smooth. That is an important distinction when shopping for anti-ageing products. A well-hydrated complexion can feel softer and look smoother, but that does not necessarily mean the product has significantly reduced the depth of existing wrinkles.

What was actually inside the creams?

OCU also looked at the ingredients and labelling of the products, which included familiar names from the anti-ageing world such as retinol, vitamins C and E, vitamin B3, Q10, hyaluronic acid and various acids.

It also found recognised allergenic fragrances in several of the creams. Xhekpon contained up to eight different allergenic fragrances, while Weleda had five. Cien and Cosmia had three each, and Nivea and Deliplus had one each.  That is particularly worth checking for anyone with sensitive skin.

So what actually helps?

OCU points to some considerably less glamorous ways of looking after your skin, including reducing exposure to ultraviolet radiation and using sun protection. It also recommends avoiding smoking, eating a balanced diet, getting enough physical activity and maintaining good sleep habits. Regularly moisturising the skin is another simple measure it recommends. 

For anyone tempted by an expensive jar promising visibly younger skin, the OCU results offer a useful reality check. The most expensive cream in the test did reduce wrinkles, but only marginally more than a €3.99 Lidl alternative. And across the 13 products tested, the bigger benefit was hydration rather than a dramatic reduction in wrinkles.